The relationship between senescence and agingTargeting senescent cellsThe benefits of senolyticsReferencesFurther reading Senolytics, a class of drugs designed to specifically target senescent cells—those that have ceased cell division—are gaining recognition for their potential to address various age-related health issues. Image Credit: LeviaUA/Shutterstock.com These cells may stop dividing due to environmental or internal conditions and serve as a protective measure when […]

What is immunobridging?What is the purpose of immunobridging?Immunobridging schematicImmunobridging and COVID-19References Further reading Controlling the ever-evolving COVID-19 epidemic requires rapid vaccine development and rollout. A vaccine cannot be lawfully disseminated in most countries without passing a thorough, placebo-controlled phase 3 efficacy trial. However, there have not been enough occurrences or volunteers in other locations to make this practicable.   ​​​​​​​Image Credit: StudioRomantic/Shutterstock.com […]

Cause and symptomsGeneticsEpidemiologyDiagnosis and treatment ReferencesFurther reading Branchiootorenal spectrum disorder (BORSD) is a group of rare autosomal dominant conditions. It is characterized by malformations of the outer, middle, and inner ear associated with hearing impairment, branchial fistulae, and renal malformations. Image Credit: Peakstock/Shutterstock.com BORSD encompasses the phenotypes previously described separately as branchiootorenal (BOR) syndrome and branchiootic (BO) syndrome, distinguished only by […]

Babies are born with brains pre-organized into areas dedicated to movement, vision, hearing and other functions, a critical infrastructure that equips them to start learning about the world from the moment they take their first breaths. But little is known about how the brain’s architecture is built because of the challenges involved in studying brain development before birth. Enter fat-tailed […]

For people who have experienced a heart attack or stroke, taking a daily aspirin has been shown to help prevent a second one. Yet, despite aspirin’s low cost and its clear benefits in such scenarios, fewer than half of people worldwide who have had a heart attack or stroke take the medication, according to a new study led by researchers […]

Treatment for: Nonalcoholic Steatohepatitis Madrigal Pharmaceuticals Announces Rolling Submission of New Drug Application to U.S. FDA Seeking Accelerated Approval of Resmetirom for the Treatment of NASH with Liver Fibrosis CONSHOHOCKEN, Pa., June 30, 2023 (GLOBE NEWSWIRE) — Madrigal Pharmaceuticals, Inc. (NASDAQ:MDGL), a clinical-stage biopharmaceutical company pursuing novel therapeutics for nonalcoholic steatohepatitis (NASH), initiated a rolling submission of a New Drug […]

Colin A. Martin, MD, a specialist in intestinal rehabilitation surgery and an advocate for diversity, equity and inclusion in surgery, has been named director of the Division of Pediatric Surgery in the Department of Surgery at Washington University School of Medicine in St. Louis. He also will serve as surgeon-in-chief at St. Louis Children’s Hospital. He will begin in his […]

Treatment for: Ulcerative Colitis U.S. Food and Drug Administration Issues Complete Response Letter for Mirikizumab INDIANAPOLIS, April 13, 2023 /PRNewswire/ — Eli Lilly and Company (NYSE: LLY) announced the U.S. Food and Drug Administration (FDA) has issued a complete response letter for the mirikizumab biologic license application (BLA) for the treatment of ulcerative colitis (UC). In the letter, the FDA […]

Generic name: tenapanor Treatment for: Hyperphosphatemia of Renal Failure Ardelyx Resubmits New Drug Application to U.S. Food and Drug Administration for Xphozah (tenapanor) WALTHAM, Mass., April 18, 2023 (GLOBE NEWSWIRE) — Ardelyx, Inc. (Nasdaq: ARDX), a biopharmaceutical company founded with a mission to discover, develop and commercialize innovative, first-in-class medicines that meet significant unmet medical needs, today announced the resubmission […]

Cause and mechanismSymptomsGenes and mutationsNADPH complexDiagnosis and treatment ReferencesFurther reading Chronic granulomatous disease (CGD) is a rare genetic immunodeficiency associated with phagocyte function. It was first described in the 1950s. It is caused due to functional impairment in the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase complex and affects 1 in 200,000 live births in the USA. Usually diagnosed at an early […]