New drug mimics benefits of ketamine for depression

A new small-molecule drug produced a rapid antidepressant response similar to that of ketamine when tested in mice, a new Yale-led study published April 16 in the Journal of Clinical Investigation shows. The effects of the drug, called NV-5138, in rodent models mimicked the rapid actions of the anesthetic ketamine, a variation of which, Esketamine, was recently approved by the […]

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New role for innate immune sensor: Suppressing liver cancer

UT Southwestern researchers have found that a protein in the body’s innate immune system that responds to gut microbes can suppress the most common type of liver cancer. The study, published today in the journal eLife, determined that NLRP12, an innate immune sensor, has a protective effect against hepatocellular carcinoma (HCC), a deadly human cancer associated with chronic inflammation. HCC […]

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Eliminating routine but low-value preoperative tests for cataract surgery patients associated with cost savings

UCLA researchers found that eliminating routine but unnecessary procedures before people undergo cataract surgery has the potential to save costs and resources for hospitals serving lower-income patients. Forgoing routine chest x-rays, electrocardiograms and other preoperative procedures—which studies have found to have no clinical benefit prior to cataract surgery—was associated with a savings of $67,241 over three years at one of […]

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Discovery aids search for cancer biomarkers

A report by researchers at Vanderbilt University Medical Center has shattered conventional wisdom about how cells, including cancer cells, shed DNA into the bloodstream: they don’t do it by packaging the genetic material in tiny vesicles called exosomes. Their findings, reported April 4 in the journal Cell, have important implications for the development of “liquid biopsies” that could speed cancer […]

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Brain-like model provides hope for millions with Alzheimer’s, other neurological disorders

Up to 1 billion people, nearly one in six of the world’s population, suffer from neurological disorders. The number of people with those disorders, including Alzheimer’s and Parkinson’s disease, has been steadily increasing in recent decades. Drug discovery and development efforts to mitigate these diseases have increased. However, those efforts have been slow to translate into clinical practices and medications […]

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Breathing exercise: 5 minutes for the blood pressure

A five-minute workout, with a resistance of the device sharply inhaled, lowered blood pressure, as well as a cardio workout, and even stronger than some drugs. You may also receive the mental capacity of this Training benefit. With an expenditure of time of only five minutes a day the arterial function and the blood of a new study found that […]

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Expert tips for reducing running injuries

(HealthDay)—Most runners are enthusiastic about their sport and take steps to work out safely. But injuries like stress fractures and muscle strains, among others, are common and can sideline you, sometimes for weeks if not months. Researchers point to hard heel-toe landings as one key injury risk factor. This type of landing increases vertical load rate—the amount of force your […]

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Is There a Cure for Lyme Disease?

In much of the country, spring and summer mean warmer weather and spending more time outdoors. Unfortunately, it also means that the ticks that carry Lyme disease bacteria may be out in full force, especially in wooded or grassy areas. About 30,000 cases of Lyme disease are reported each year to the U.S. Centers for Disease Control and Prevention, although […]

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5 Easy Barbell Exercises for Beginners

Cardio is great—in fact, it’s a must. But there’s another beneficial component to physical fitness that many women are ignoring: weight lifting. And we’re not just talking about picking up those little 2-pound weights and doing a few bicep curls (though there’s nothing wrong with that). Hitting the weight room—and more specifically, using a barbell—challenges your body in a way […]

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