New approach to pain treatment in diseases of the pancreas

One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain. Pancreatic pain is difficult to treat, because many painkillers prove ineffective in pancreatic patients. In a recent study, a team at the Technical University of Munich (TUM) discovered the cause of this phenomenon for the first time: a particular neuroenzyme in the body […]

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No benefit found for high-dose vitamin C infusions in sepsis, ARDS

(HealthDay)—Compared with placebo, intravenous infusion of high-dose vitamin C does not improve organ dysfunction or alter markers of inflammation or vascular injury among patients with sepsis and acute respiratory distress syndrome (ARDS), according to a study published in the Oct. 1 issue of the Journal of the American Medical Association. Alpha A. Fowler III, M.D., from Virginia Commonwealth University in […]

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Big box pharmacies offer lowest cash prices for generic drugs

Compared with large chains, independent pharmacies and small chains had the highest cash prices for generic drugs and big-box pharmacies the lowest. Cash prices for brand-name drugs were similar across all types of retail pharmacies. Findings from a national cross-sectional study are published in Annals of Internal Medicine. Researchers from Brigham and Women’s Hospital used data from GoodRx, an online […]

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More blood pressure drugs recalled

The recall of the commonly prescribed blood pressure drug losartan has been expanded once again to include an additional five lots. The drug, made by Torrent Pharmaceuticals, has been recalled because some lots are contaminated with the cancer-causing chemical N-methylnitrosobutyric acid, according to a company press release. The drugs added to the recall include lots of Losartan Potassium Tablets, USP, […]

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Amid settlement talks, opioids keep taking a grim toll

As the nation’s attorneys general debate a legal settlement with Purdue Pharma, the opioid epidemic associated with its blockbuster painkiller OxyContin rages on in state after state, community after community, killing tens of thousands of people each year with no end in sight. In Pennsylvania’s York County, the coroner investigated eight suspected overdose deaths in a single week of August—four […]

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Full chemo doses may improve survival in breast cancer

(HealthDay)—Maintaining full doses of chemotherapy, especially early in the treatment course, is important for survival of intermediate or high-risk breast cancer patients, according to a study published in the August issue of the Journal of the National Comprehensive Cancer Network. Zachary Veitch, M.D., from the University of Calgary in Canada, and colleagues evaluated the impact of chemotherapy total cumulative dose […]

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Popular pain medication associated with greater risk of hypoglycemia

Since its approval in 1995, the opioid tramadol (marketed as ConZip and Ultram) has become a widely prescribed remedy for osteoarthritis and other painful indications, in part because it presents a lesser risk for some side effects and has a lower abuse potential when compared to other opioids. It is currently ranked among the top five prescribed opioids and top […]

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PET imaging shows if PD-1 cancer immunotherapy is working

PD-1 is a protein on our T cells that normally keeps these immune cells from running amok. A growing number of cancer drugs are designed to inhibit PD-1, enabling patients’ T-cells to attack and kill cancerous cells. PD-1 blockers such as pembrolizumab (Keytruda) have been helpful in treating several cancers including melanoma, non-small cell lung cancer, kidney cancer, bladder cancer, […]

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Millions of children exposed to opioid misuse at home, new study reveals

More than 3.8 million U.S. children live with an adult who is inappropriately using opioids, according to a new estimate from the Georgia Institute of Technology’s School of Public Policy. The study, which spans the years 2002 to 2017, also found that while fewer children are living with someone who casually misuses opioids, the number living with adults exhibiting signs […]

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