Protein loss promotes cell migration

The protein STK17A (serine threonine kinase 17A) appears to play roles in various cancer types. It can be oncogenic or tumor suppressive, depending on the cancer, but its role in colorectal cancer has not been established. Christopher Williams, MD, PhD, Sarah Short, PhD, and colleagues observed that STK17A expression is reduced in primary colorectal tumors and even further reduced in […]

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Researchers use health data tools to rapidly detect sepsis in newborns

Automated programs can identify which sick infants in a neonatal intensive care unit (NICU) have sepsis hours before clinicians recognize the life-threatening condition. A team of data researchers and physician-scientists tested machine-learning models in a NICU population, drawing only on routinely collected data available in electronic health records (EHRs). “Because early detection and rapid intervention is essential in cases of […]

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Study of singing mice suggests how mammalian brain achieves conversation

By studying the songs of mice from the cloud forests of Costa Rica, researchers have discovered a brain circuit that may enable the high-speed back and forth of conversation. Males of the study species, Alston’s singing mouse (Scotinomys teguina), produce songs with nearly a hundred audible notes. They challenge competitors by singing in turns, alternating like talking humans, say the […]

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Research changes GP guidelines on frailty in diabetes

New guidelines will help GPs get the best outcomes for older people with diabetes after they were changed to include specific advice around frailty. The newly revised GP contract, a five-year framework for GPs, includes the first specific guidance around how and when to stop treatment diabetes in particularly frail older people. The new guidance is informed by research led […]

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Cancer survivors urgently need funded rehabilitation care

There are now more than 17 million cancer survivors in North America and this number is expected to increase to close to 30 million by 2040. This is without doubt a good news story, reflecting an impressive 27 per cent drop in the number of people dying from cancer over the past 25 years. However, it is important to recognize […]

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Discovery of colon cancer pathway could lead to new targeted treatments

University of Massachusetts Amherst food science researchers have pinpointed a set of enzymes involved in tumor growth that could be targeted to prevent or treat colon cancer. “We think this is a very interesting discovery,” says Guodong Zhang, assistant professor of food science, whose study was published in the journal Cancer Research. “Our research identifies a novel therapeutic target and […]

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Research team eradicates Hepatitis C in patients after heart transplants from infected donors

Nine patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving heart transplants from deceased donors who were infected with the disease, according to a study published in the American Journal of Transplantation. The results highlight the potential for expanding the use of HCV-infected organs, including hearts, to broaden the donor pool for the more […]

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Fat cells work different ‘shifts’ throughout the day

Fat cells in the human body have their own internal clocks and exhibit circadian rhythms affecting critical metabolic functions, new research in the journal Scientific Reports, finds. Researchers led by Dr. Jonathan Johnston from the University of Surrey conducted the first ever analysis of circadian rhythms in human fat taken from people isolated from daily environmental changes. Circadian rhythms are […]

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Discovery of new ‘checkpoint’ points to new cancer immunotherapy option

An international team involving Vanderbilt researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it—in combination with other treatments—is a successful therapeutic approach in mouse models of cancer. The findings were reported in the journal Cell. Checkpoint proteins are regulators of the immune response; they put on the “brakes” to […]

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